Nausea and vomiting are common complaints seen in a variety of settings. The cause may be associated with something as innocuous as spinning too fast on an amusement park ride. It also may be a therapy induced adverse reaction, or a symptom in a much more serious and complicated clinical presentation. Nausea and vomiting may occur independently, but generally they are closely allied and are presumed to be mediated by the same neural pathway, and therefore will be discussed together. Nausea denotes the imminent desire to vomit, usually referred to the throat or epigastrium. Vomiting (or emesis) refers to the forceful oral expulsion of gastric contents. Retching denotes the labored rhythmic contraction of respiratory and abdominal musculature that frequently precedes or accompanies vomiting
Coenzyme Q10 (CoQ10) is an important nutrient in the human body. It is a fat-soluble vitamin-like compound that is also known as ubiquinone from the word ubiquitous, which means “everywhere.” Coenzyme Q or ubiquinone compounds are synthesized in the cells of all living organisms including plants, animals, and humans. There are 10 coenzyme Q compounds that occur throughout nature, but only coenzyme Q10 is synthesized in humans. It is probable that many people with health problems are suffering from a coenzyme Q10 deficiency due to inadequate dietary intake of the necessary nutrients and/or ingestion of one or more drugs that interrupt the synthesis of coenzyme Q10. The symptoms of coenzyme Q10 deficiency include: congestive heart failure, high blood pressure, angina, mitral valve prolapse, stroke, cardiac arrhythmias, cardiomyopathies, lack of energy, gingivitis, and a generalized weakening of the immune system.
Cyclic vomiting syndrome (CVS) is a condition of recurring attacks of intense nausea, vomiting and sometimes abdominal pain and is associated with migraine headaches and mitochondrial dysfunction. There are not very many studies on Co-Q10’s effectiveness in treating CVS so researchers decided to investigate Co-Q10 and CVS. They used an internet-based survey completed by patients with CVS or their parents for efficacy, tolerability and patient satisfaction of Co-Q10 or amitriptyline. Of the 22 subjects receiving Co-Q10, 68 percent reported at least a 50 percent reduction in the frequency, duration, or severity of episodes as well as of the 162 subjects, 72 percent also had the same outcome. However, the patients taking Co-Q10 did not have any side effects where as one half of the patients taking amitriptyline reported side effects and 21 percent of the patients discontinued treatment because of these side effects. The researchers concluded that their data suggest that Co-Q10 is effective and tolerable and should be considered as an option in the treatment of cyclic vomiting syndrome.1
1 Boles RG, Lovett-Barr MR, Preston A, et al. Treatment of cyclic vomiting syndrome with co-enzyme Q10 and amitriptyline, a retrospective study. BMC Neurol. 2010;10:10.